Like, for instance, you shouldn't have a career in science?
You know how it is--you're trying to accomplish something, nothing is working, in fact, everything seems to be working against you, and it starts to feel like God or the Universe or whatever Powers That Be are doing this to subtly or not-so-subtly tell you, hey, it's not a good idea for you to do that. That's how I feel in lab lately. Nothing seems to work properly, and tomorrow I have to present at lab meeting and I get the not-so-gratifying distinction of standing up there and saying that I have accomplished absolutely nothing in the last several months since the last lab meeting.
Why am I doing this again?